OneMedPlace Releases Update to Research Report on Amarantus Biosciences Focused on New Positive Ischemic Heart Disease Efficacy Data for MANF in Animals

SUNNYVALE, Calif. and NEW YORK, Nov. 23, 2012 /PRNewswire/ -- Amarantus BioSciences, Inc. (OTCQB: AMBS), a biotechnology company developing new treatments and diagnostics for Parkinson's disease and Traumatic Brain Injury centered on its proprietary anti-apoptosis therapeutic protein MANF, today announced that OneMedPlace's Research Division has released an update to its previous research report on Amarantus Biosciences, highlighting recently announced positive ischemic heart disease (myocardial infarction, heart attack) efficacy data for MANF in animals. The updated research report focuses on the mechanisms of action by which MANF functions to protect heart cells under conditions that simulate ischemic heart disease in animals. The updated research report from OneMedPlace Research can be found online at http://www.onemedplace.com/reports/Amarantus_Research_Update_112012.pdf.

The report states: "The results showed that MANF has a robust ability to protect the heart; during episodes of ischemia-reperfusion injury, hearts treated with MANF had 40% less total area of cell death as compared control hearts that did not receive treatment. These data serve as strong evidence that positions MANF as a potential breakthrough therapeutic treatment for ischemic heart conditions. This study adds to an accumulating body of research that all corroborate the therapeutic effects of MANF. Since its original discovery in 2003, MANF has been the subject of over 20 independent studies that identify its ability to treat disease states. MANF has been shown to stop disease progression in animal models of Parkinson's disease, protect the heart in instances of chemically induced toxicity, and in this work, protect against ischemia-reperfusion heart injury. Taken together these studies delineate the vast potential of MANF as a therapeutic, providing Amarantus with the requisite empirical evidence needed to propel this drug candidate into advanced developmental stages and clinical trials."

Ischemia-reperfusion injury within the context of acute ischemic heart disease (myocardial infarction) is one of the major causes of long-term disability following cardiovascular events. Treatments for ischemia reperfusion emain a key unmet medical needs in treating cardiovascular events, as there are currently no approved therapies that address this critical biological pathway that is responsible for significant side effects. The market opportunity for a drug that significantly reduces infarct zone size following cardiovascular events exceeds $1 billion annually.

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